High concentration subcutaneous (SC) dosing regimens are desirable for monoclonal antibody (MAb) therapeutics to ensure patient convenience, manufacturing ease as well as product marketability. High protein concentration often results in a dramatic increase in solution viscosity and self-association issues, which remain critical concerns in formulation development. ^ The effect of different variables, pertaining to both inherent molecular and solution properties, on the viscosity of different MAbs was systematically analyzed. The high concentration viscosity behavior could not be explained based on the net charge, effective molecular size and/or excluded volume effects. The nature of intermolecular interactions governed the high concentra...
The viscosity of a monoclonal antibody solution must be monitored and controlled as it can adversely...
Development of high concentration liquid formulations is especially attractive for biopharmaceutical...
Solution viscosities (η) and protein–protein interactions (PPI) of three monoclonal antibodies (mAb-...
High concentration subcutaneous (SC) dosing regimens are desirable for monoclonal antibody (MAb) the...
Solutions of monoclonal antibodies (mAbs) at high concentration are strongly desirable for subcutane...
The present work investigates the influence of electrostatic surface potential distribution of monoc...
High protein titers are gaining importance in biopharmaceutical industry. A major challenge in the d...
The ability to design and formulate mAbs to minimize attractive interactions at high concentrations ...
AbstractWeak protein-protein interactions are thought to modulate the viscoelastic properties of con...
The purpose of this work was to elucidate the molecular interactions leading to monoclonal antibody ...
Highly concentrated (> 200 mg/mL) monoclonal antibody (mAb) formulations with low viscosities are st...
Protein-based therapeutics such as monoclonal antibodies (mAbs) and related fragments are increasing...
From PubMed via Jisc Publications RouterHistory: received 2021-06-04, revised 2021-07-28, accepted 2...
In this study, we used sodium chloride (NaCl) to extensively modulate non-specific protein-protein i...
Purpose: The aim of this study was to markedly lower the viscosities of highly concentrated protein...
The viscosity of a monoclonal antibody solution must be monitored and controlled as it can adversely...
Development of high concentration liquid formulations is especially attractive for biopharmaceutical...
Solution viscosities (η) and protein–protein interactions (PPI) of three monoclonal antibodies (mAb-...
High concentration subcutaneous (SC) dosing regimens are desirable for monoclonal antibody (MAb) the...
Solutions of monoclonal antibodies (mAbs) at high concentration are strongly desirable for subcutane...
The present work investigates the influence of electrostatic surface potential distribution of monoc...
High protein titers are gaining importance in biopharmaceutical industry. A major challenge in the d...
The ability to design and formulate mAbs to minimize attractive interactions at high concentrations ...
AbstractWeak protein-protein interactions are thought to modulate the viscoelastic properties of con...
The purpose of this work was to elucidate the molecular interactions leading to monoclonal antibody ...
Highly concentrated (> 200 mg/mL) monoclonal antibody (mAb) formulations with low viscosities are st...
Protein-based therapeutics such as monoclonal antibodies (mAbs) and related fragments are increasing...
From PubMed via Jisc Publications RouterHistory: received 2021-06-04, revised 2021-07-28, accepted 2...
In this study, we used sodium chloride (NaCl) to extensively modulate non-specific protein-protein i...
Purpose: The aim of this study was to markedly lower the viscosities of highly concentrated protein...
The viscosity of a monoclonal antibody solution must be monitored and controlled as it can adversely...
Development of high concentration liquid formulations is especially attractive for biopharmaceutical...
Solution viscosities (η) and protein–protein interactions (PPI) of three monoclonal antibodies (mAb-...