The special issue of 1st ProSES Symposium is a collection of invited contributions from the presenters of the inaugural Process Systems Engineering & Safety (ProSES) Symposium, organized by Process Systems Engineering & Safety (ProSES) Research Group, Faculty of Chemical and Process Engineering Technology, formally known as the Faculty of Chemical and Natural Resources Engineering, Universiti Malaysia Pahang, on 4th September 2019 in Kuantan, Pahang, Malaysia. The theme for the 1st ProSES Symposium 2019 is The Role of Modelling and Simulation Towards IR 4.0, since the emergence of IR4.0 technology provides the opportunity for dramatically increasing the reliability and efficiency in production operations of many industrial sectors including...