A two decade dementia incidence comparison from the Cognitive Function and Ageing Studies i and II
- Matthews, F. E.
- Stephan, B. C M
- Robinson, L.
- Jagger, C.
- Barnes, L. E.
- Arthur, A.
- Brayne, C.
- Comas-Herrera, A.
- Wittenberg, R.
- Dening, T.
- McCracke, C. F M
- Moody, C.
- Parry, Bron
- Green, E.
- Barnes, R.
- Warwick, J.
- Gao, L.
- Mattison, A.
- Baldwin, C.
- Harrison, S.
- Woods, B.
- McKeit, I. G.
- Ince, P. G.
- Wharton, S. B.
- Forster, G.
DOIAbstract
Dramatic global increases in future numbers of people with dementia have been predicted. No multicentre population-based study powered to detect changes over time has reported dementia incidence. MRC Cognitive Function and Ageing Study (CFAS) undertook baseline interviews in populations aged 65+ years in England and Wales (1989-1994). Three areas (CFAS I) were selected for new sampling two decades later (2008-2011) with same geographical boundaries, sampling and approach methods (CFAS II). At 2 years CFAS I interviewed 5,156 (76% response) with 5,288 interviewed in CFAS II (74% response). Here we report a 20% drop in incidence (95% CI: 0-40%), driven by a reduction in men across all ages above 65. In the UK we estimate 209,600 new dementia ...
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