Neural development from blastocysts is strictly controlled by intricate transcriptional programmes that initiate the down-regulation of pluripotent genes, Oct4, Nanog and Rex1 in blastocysts followed by up-regulation of lineage-specific genes as neural development proceeds. Here, we demonstrate that the expression pattern of the transcription factor Rest mirrors those of pluripotent genes during neural development from embryonic stem (ES) cells and an early abrogation of Rest in ES cells using a combination of gene targeting and RNAi approaches causes defects in this process. Specifically, Rest ablation does not alter ES cell pluripotency, but impedes the production of Nestin(+) neural stem cells, neural progenitor cells and neurons, and re...
The RE-1 silencing transcription factor (REST) is an important regulator of normal nervous system de...
Cell epigenomics depends on the marks released by transcription factors operating via the assembly o...
REST is abundantly expressed in mouse embryonic stem cells (ESCs). Many genome-wide analyses have fo...
Neural development from blastocysts is strictly controlled by intricate transcriptional programmes t...
Neural differentiation of embryonic stem cells (ESCs) requires coordinated repression of the pluripo...
Neural stem cell (NSC) properties are finely regulated by changes in their transcriptional program. ...
Directing differentiation of neural stem/progenitor cells (NPCs) to produce functional neurons is a ...
SummaryRegulation of neuronal gene expression is critical to central nervous system development. Her...
REST (RE1 silencing transcription factor), also known as NRSF (neuron-restrictive silencer factor), ...
Includes bibliographical references (pages 58-62)Human embryonic stem cells (hESCs) have the unique ...
<div><p>REST (RE1 silencing transcription factor), also known as NRSF (neuron-restrictive silencer f...
Adult neural stem cell (aNSC) activity is tuned by external stimuli through the recruitment of trans...
REST (RE1 silencing transcription factor), also known as NRSF (neuron-restrictive silencer factor), ...
STUDY OF REST AS A NEGATIVE REGULATOR OF P16INK4A Monica Gireud, B.S. Thesis Advisor: Vidya Gopalak...
The neuron-restrictive silencer factor NRSF (also known as REST and XBR) can silence transcription f...
The RE-1 silencing transcription factor (REST) is an important regulator of normal nervous system de...
Cell epigenomics depends on the marks released by transcription factors operating via the assembly o...
REST is abundantly expressed in mouse embryonic stem cells (ESCs). Many genome-wide analyses have fo...
Neural development from blastocysts is strictly controlled by intricate transcriptional programmes t...
Neural differentiation of embryonic stem cells (ESCs) requires coordinated repression of the pluripo...
Neural stem cell (NSC) properties are finely regulated by changes in their transcriptional program. ...
Directing differentiation of neural stem/progenitor cells (NPCs) to produce functional neurons is a ...
SummaryRegulation of neuronal gene expression is critical to central nervous system development. Her...
REST (RE1 silencing transcription factor), also known as NRSF (neuron-restrictive silencer factor), ...
Includes bibliographical references (pages 58-62)Human embryonic stem cells (hESCs) have the unique ...
<div><p>REST (RE1 silencing transcription factor), also known as NRSF (neuron-restrictive silencer f...
Adult neural stem cell (aNSC) activity is tuned by external stimuli through the recruitment of trans...
REST (RE1 silencing transcription factor), also known as NRSF (neuron-restrictive silencer factor), ...
STUDY OF REST AS A NEGATIVE REGULATOR OF P16INK4A Monica Gireud, B.S. Thesis Advisor: Vidya Gopalak...
The neuron-restrictive silencer factor NRSF (also known as REST and XBR) can silence transcription f...
The RE-1 silencing transcription factor (REST) is an important regulator of normal nervous system de...
Cell epigenomics depends on the marks released by transcription factors operating via the assembly o...
REST is abundantly expressed in mouse embryonic stem cells (ESCs). Many genome-wide analyses have fo...