Regulation of T cell immunity by C5a has been suggested from recent studies. However, the underlying mechanisms, particularly the involved cells and biochemical basis, are not well defined. In this study, the direct modulation of dendritic cell (DC) activation and its function in T cell stimulation by C5a-C5aR interaction and the involved signaling pathways were investigated. We show that DCs from C5aR(-/-) mice and normal DCs treated with C5aR antagonist have less-activated phenotype characterized with increased IL-10 and decreased IL-12p70 production in response to LPS stimulation, lowered surface expression of MHC class II, B7.2, and consequently have reduced capacity to stimulate allospecific T cells. Conversely, C5a stimulation up-regu...
SummaryCostimulatory signals are critical to T cell activation, but how their effects are mediated r...
The complement activation fragment C5a is a potent proinflammatory mediator that is increasingly rec...
TLR and complement activation ensures efficient clearance of infection. Previous studies documented ...
Regulation of T cell immunity by C5a has been suggested from recent studies. However, the underlying...
Activation of antigen-presenting dendritic cells (DCs) and the complement system are essential early...
Dendritic cells (DCs) and the complement system are two essential parts of our immune system, that a...
AbstractAnaphylatoxins C3a and C5a are important modulators for dendritic cell activation and functi...
Crosstalk between complement component 5a receptors (C5aRs) and TLRs in dendritic cells (DCs) occurs...
The role of CD5 as a regulator of T cell signaling and tolerance is well recognized. Recent data sho...
The complement anaphylatoxin, C5a has been implicated in regulation of adaptive immune responses thr...
Complement is a critical component of the innate immune system tasked with host defense against inva...
SummaryThe complement system and the Toll-like receptors (TLRs) are two central arms of innate immun...
Although extrahepatic synthesis of complement and particularly C3 has been widely studied in most ce...
The complement system is a classic central player in innate immunity. Most pathogens activate both c...
The biological significance of C5a receptor [(C5aR)2/C5L2], a seven-transmembrane receptor binding C...
SummaryCostimulatory signals are critical to T cell activation, but how their effects are mediated r...
The complement activation fragment C5a is a potent proinflammatory mediator that is increasingly rec...
TLR and complement activation ensures efficient clearance of infection. Previous studies documented ...
Regulation of T cell immunity by C5a has been suggested from recent studies. However, the underlying...
Activation of antigen-presenting dendritic cells (DCs) and the complement system are essential early...
Dendritic cells (DCs) and the complement system are two essential parts of our immune system, that a...
AbstractAnaphylatoxins C3a and C5a are important modulators for dendritic cell activation and functi...
Crosstalk between complement component 5a receptors (C5aRs) and TLRs in dendritic cells (DCs) occurs...
The role of CD5 as a regulator of T cell signaling and tolerance is well recognized. Recent data sho...
The complement anaphylatoxin, C5a has been implicated in regulation of adaptive immune responses thr...
Complement is a critical component of the innate immune system tasked with host defense against inva...
SummaryThe complement system and the Toll-like receptors (TLRs) are two central arms of innate immun...
Although extrahepatic synthesis of complement and particularly C3 has been widely studied in most ce...
The complement system is a classic central player in innate immunity. Most pathogens activate both c...
The biological significance of C5a receptor [(C5aR)2/C5L2], a seven-transmembrane receptor binding C...
SummaryCostimulatory signals are critical to T cell activation, but how their effects are mediated r...
The complement activation fragment C5a is a potent proinflammatory mediator that is increasingly rec...
TLR and complement activation ensures efficient clearance of infection. Previous studies documented ...