Although GWASs have been conducted to investigate genetic variation of bladder tumorigenesis, little is known about genetic interactions that may influence bladder cancer (BC) risk. By leveraging large-scale participants from UK Biobank, we established a discovery database with 4000 Caucasian participants (2000 cases vs 2000 non-cases), a database with 1648 Caucasian participants (824 cases vs 824 non-cases) and 856 non-Caucasian participants (428 cases vs 428 non-cases) as validation. We then performed a genome-wide SNP-SNP interaction investigation related to BC risk based a machine learning approach (ie, GenEpi). Moreover, we used the selected interactions to build a BC screening model with an integrated interaction-empowered polygenic r...
We conducted a multi-stage, genome-wide association study of bladder cancer with a primary scan of 5...
PURPOSE OF REVIEW: The role of genetic susceptibility in the development of urinary bladder cancer i...
Objectives: To investigate the association of polygenic risk score (PRS) and bladder cancer (BC) ris...
Although GWASs have been conducted to investigate genetic variation of bladder tumorigenesis, little...
Candidate gene and genome-wide association studies (GWAS) have identified 11 independent susceptibil...
Contains fulltext : 181627.pdf (Publisher’s version ) (Open Access)Little is known...
Genome-wide association studies (GWAS) of urinary bladder cancer (UBC) have yielded common variants ...
The aetiology of bladder cancer (BC) is still not fully understood. Genetic factors and many differe...
Genome-wide association studies (GWAS) of urinary bladder cancer (UBC) have yielded common variants ...
Little is known whether genetic variants identified in genome-wide association studi...
Background: Bladder cancer is common disease with a complex etiology that is likely due to many diff...
Bladder cancer is a complex disease with known environmental and genetic risk factors. We performed ...
We conducted a multi-stage, genome-wide association study of bladder cancer with a primary scan of 5...
PURPOSE OF REVIEW: The role of genetic susceptibility in the development of urinary bladder cancer i...
Objectives: To investigate the association of polygenic risk score (PRS) and bladder cancer (BC) ris...
Although GWASs have been conducted to investigate genetic variation of bladder tumorigenesis, little...
Candidate gene and genome-wide association studies (GWAS) have identified 11 independent susceptibil...
Contains fulltext : 181627.pdf (Publisher’s version ) (Open Access)Little is known...
Genome-wide association studies (GWAS) of urinary bladder cancer (UBC) have yielded common variants ...
The aetiology of bladder cancer (BC) is still not fully understood. Genetic factors and many differe...
Genome-wide association studies (GWAS) of urinary bladder cancer (UBC) have yielded common variants ...
Little is known whether genetic variants identified in genome-wide association studi...
Background: Bladder cancer is common disease with a complex etiology that is likely due to many diff...
Bladder cancer is a complex disease with known environmental and genetic risk factors. We performed ...
We conducted a multi-stage, genome-wide association study of bladder cancer with a primary scan of 5...
PURPOSE OF REVIEW: The role of genetic susceptibility in the development of urinary bladder cancer i...
Objectives: To investigate the association of polygenic risk score (PRS) and bladder cancer (BC) ris...