This bachelor thesis explains nuclear power plants, mainly the description of the nuclear fuel cycle. At the beginning, the principle of nuclear fission and a description of the thermal cycle are explained. The work also describes different types of nuclear reactors divided by generation. The main focus of this work is the fuel cycle, where various technologies of uranium ore mining, its processing, enrichment, fuel rods and subsequent handling of spent fuel are described. The final part describes the effectiveness of nuclear power plants in terms of thermal efficiency, as well as safety and environmental impact