The epidermal growth factor receptor (EGFR) is one of the main tumor drivers and is an important therapeutic target for many cancers. Calcium is important in EGFR signaling pathways. Sorcin is one of the most important calcium sensor proteins, overexpressed in many tumors, that promotes cell proliferation, migration, invasion, epithelial-to-mesenchymal transition, malignant progression and resistance to chemotherapeutic drugs. The present work elucidates a functional mechanism that links calcium homeostasis to EGFR signaling in cancer. Sorcin and EGFR expression are significantly correlated and associated with reduced overall survival in cancer patients. Mechanistically, Sorcin directly binds EGFR protein in a calcium-dependent fashion and ...
Dysregulation of calcium signaling is emerging as a key feature in the pathogenesis of neurodegenera...
Sorcin is a calcium binding protein that plays an important role in multidrug resistance (MDR) in tu...
Epidermal growth factor receptor (ErbB1) and somatostatin receptors (SSTRs) exert opposing effects o...
The epidermal growth factor receptor (EGFR) is one of the main tumor drivers, and is an important th...
Sorcin (Soluble resistance related calcium binding protein) is a small soluble penta EF family (PEF)...
Sorcin is an essential penta-EF hand calcium binding protein, able to confer the multi-...
Sorcin, a 22-kDa calcium-binding protein, renders cancer cells resistant to chemotherapeutic agents,...
Soluble resistance-related calcium binding protein (Sorcin) is a protein initially labelled “resista...
Sorcin is a penta-EF hand calcium binding protein, which participates in the regulation of calcium h...
Sorcin is calcium-binding oncoprotein overexpressed in several human tumors, is a marker of Multi-Dr...
The development of drug resistance is one of the main causes of failure in anti-cancer treatments. T...
The development of drug resistance is one of the main causes of failure in anti-cancer treatments. T...
The development of drug resistance is one of the main causes of failure in anti-cancer treatments. T...
The physiological function of the epidermal growth factor receptor (EGFR) is to regulate epithelial ...
<div><p>Sorcin, a protein overexpressed in many multi-drug resistant cancers, dynamically localizes ...
Dysregulation of calcium signaling is emerging as a key feature in the pathogenesis of neurodegenera...
Sorcin is a calcium binding protein that plays an important role in multidrug resistance (MDR) in tu...
Epidermal growth factor receptor (ErbB1) and somatostatin receptors (SSTRs) exert opposing effects o...
The epidermal growth factor receptor (EGFR) is one of the main tumor drivers, and is an important th...
Sorcin (Soluble resistance related calcium binding protein) is a small soluble penta EF family (PEF)...
Sorcin is an essential penta-EF hand calcium binding protein, able to confer the multi-...
Sorcin, a 22-kDa calcium-binding protein, renders cancer cells resistant to chemotherapeutic agents,...
Soluble resistance-related calcium binding protein (Sorcin) is a protein initially labelled “resista...
Sorcin is a penta-EF hand calcium binding protein, which participates in the regulation of calcium h...
Sorcin is calcium-binding oncoprotein overexpressed in several human tumors, is a marker of Multi-Dr...
The development of drug resistance is one of the main causes of failure in anti-cancer treatments. T...
The development of drug resistance is one of the main causes of failure in anti-cancer treatments. T...
The development of drug resistance is one of the main causes of failure in anti-cancer treatments. T...
The physiological function of the epidermal growth factor receptor (EGFR) is to regulate epithelial ...
<div><p>Sorcin, a protein overexpressed in many multi-drug resistant cancers, dynamically localizes ...
Dysregulation of calcium signaling is emerging as a key feature in the pathogenesis of neurodegenera...
Sorcin is a calcium binding protein that plays an important role in multidrug resistance (MDR) in tu...
Epidermal growth factor receptor (ErbB1) and somatostatin receptors (SSTRs) exert opposing effects o...