Add to ORKGBackground Impaired wound healing is a growing medical problem and very few approved drugs with documented clinical efficacy are available. CXCL12-expressing lactic acid bacteria, Limosilaoocillus reuteri (ILP100-Topical), has been demonstrated to accelerate wound healing in controlled preclinical models. In this first-in-human study, the primary objective was to determine safety and tolerability of the drug candidate ILP100-Topical, while secondary objectives included assessments of clinical and biologic effects on wound healing by traditionally accepted methods and explorative and traceable assessments. Methods SITU-SAFE is an adaptive, randomised, double-blind, placebo-controlled, first-in-human phase 1 trial (EudraCT 2019-000680-24) con...
Current research on wound infections is primarily conducted on animal models, which limits direct tr...
Current research on wound infections is primarily conducted on animal models, which limits direct tr...
The topical application of lactic acid bacteria (LAB) is recognized as a useful approach to improve ...
Background Impaired wound healing is a growing medical problem and very few approved drugs with docu...
Background: Impaired wound healing is a growing medical problem and very few approved drugs with doc...
Non-healing wounds are a growing medical problem and result in considerable suffering. The lack of p...
Non-healing wounds is a growing medical problem, often associated with pathological conditions such ...
Impaired wound closure is a growing medical problem associated with metabolic diseases and aging. Im...
Ulceration of the foot in diabetes is common and disabling, and frequently leads to amputation of th...
Context: It is necessary to advance the field of alternative treatments for chronic wounds that are ...
Chronic wound formation is an affliction that disproportionately affects those of lower socioeconomi...
Current research on wound infections is primarily conducted on animal models, which limits direct tr...
Current research on wound infections is primarily conducted on animal models, which limits direct tr...
The topical application of lactic acid bacteria (LAB) is recognized as a useful approach to improve ...
Background Impaired wound healing is a growing medical problem and very few approved drugs with docu...
Background: Impaired wound healing is a growing medical problem and very few approved drugs with doc...
Non-healing wounds are a growing medical problem and result in considerable suffering. The lack of p...
Non-healing wounds is a growing medical problem, often associated with pathological conditions such ...
Impaired wound closure is a growing medical problem associated with metabolic diseases and aging. Im...
Ulceration of the foot in diabetes is common and disabling, and frequently leads to amputation of th...
Context: It is necessary to advance the field of alternative treatments for chronic wounds that are ...
Chronic wound formation is an affliction that disproportionately affects those of lower socioeconomi...
Current research on wound infections is primarily conducted on animal models, which limits direct tr...
Current research on wound infections is primarily conducted on animal models, which limits direct tr...
The topical application of lactic acid bacteria (LAB) is recognized as a useful approach to improve ...