Mitochondrial distribution determine [ATP] : [ADP] ratio and thereby energetic states of cells.

A: Box plot of the final average values of the [ATP] : [ADP] for Uniform, Polarised and Polarised (Mean in red and median in blue). B: (top) scatter plot of the ratio against LAC final average values. There are two distinct clusters between the Polarised cells and the uniformly distributed ones. (bottom) Zoom on the ratio against LAC for Polarised cells colored based on the region where we can find the mitochondria with the highest y-coordinate. Interestingly if the enzymes are well distributed inside the domain, so if there is at least one mitochondria with a y-coordinate larger than 100 (black), the ratio value is higher. On the other hand, if the mitochondria are all located within the first or second region (yellow and orange), with y-coordinate lower than 60, the cell is in unhealthy status. C: Mitochondria activity of the configurations with maximum ATP production for the three types of cells at steady state where the activity indicates which mitochondria between the ones presented in panel D are producing ATP. D: Reaction sites setting for the maximum level of ATP for the three distributions.