The structure-activity relationship was investigated in a series of synthetic TLR4 antagonists formed by a glucosamine core linked to two phosphate esters and two linear carbon chains. Molecular modeling showed that the compounds with 10, 12 and 14 carbons chains are associated to higher stabilization of the MD-2/TLR4 antagonist conformation than in the case of the C16 variant. Binding experiments with human MD-2 showed that the C12 and C14 variants have higher affinity than C10, while the C16 variant did not interact with the protein. The molecules, with the exception of the C16 variant, inhibited the LPS-stimulated TLR4 signal in human and murine cells and the antagonist potency mirrored the MD-2 affinity calculated from in vitro binding ...
AbstractA literature review concerning the unexpected species differences of the vertebrate innate i...
The best-characterized Toll-like receptor 4 (TLR4) ligands are lipopolysaccharide (LPS) and its chem...
Previous high throughput screening studies led to the discovery of two novel, nonlipid-like chemotyp...
The structure-activity relationship was investigated in a series of synthetic TLR4 antagonists forme...
The structure–activity relationship was investigated in a series of synthetic TLR4 antagonists forme...
The structure-activity relationship was investigated in a series of synthetic TLR4 antagonists forme...
The structure–activity relationship was investigated in a series of synthetic TLR4 antagonists forme...
Toll-like receptor 4 (TLR4), along with its accessory protein myeloid differentiation factor 2 (MD-2...
24 p.-10 fig.Toll-like receptor 4 (TLR4), along with its accessory protein myeloid differentiation f...
New monosaccharide-based lipid A analogues were rationally designed through MD-2 docking studies. A ...
A literature review concerning the unexpected species differences of the vertebrate innate immune re...
SummaryTLR4 and MD-2 form a heterodimer that recognizes LPS (lipopolysaccharide) from Gram-negative ...
Despite significant advances made in the last decade in the understanding of molecular mechanisms of...
New monosaccharide-based lipid A analogues were rationally designed through MD-2 docking studies. A ...
Toll-like receptor (TLR) stimulation has been implicated as amajor contributor to chronic inflammati...
AbstractA literature review concerning the unexpected species differences of the vertebrate innate i...
The best-characterized Toll-like receptor 4 (TLR4) ligands are lipopolysaccharide (LPS) and its chem...
Previous high throughput screening studies led to the discovery of two novel, nonlipid-like chemotyp...
The structure-activity relationship was investigated in a series of synthetic TLR4 antagonists forme...
The structure–activity relationship was investigated in a series of synthetic TLR4 antagonists forme...
The structure-activity relationship was investigated in a series of synthetic TLR4 antagonists forme...
The structure–activity relationship was investigated in a series of synthetic TLR4 antagonists forme...
Toll-like receptor 4 (TLR4), along with its accessory protein myeloid differentiation factor 2 (MD-2...
24 p.-10 fig.Toll-like receptor 4 (TLR4), along with its accessory protein myeloid differentiation f...
New monosaccharide-based lipid A analogues were rationally designed through MD-2 docking studies. A ...
A literature review concerning the unexpected species differences of the vertebrate innate immune re...
SummaryTLR4 and MD-2 form a heterodimer that recognizes LPS (lipopolysaccharide) from Gram-negative ...
Despite significant advances made in the last decade in the understanding of molecular mechanisms of...
New monosaccharide-based lipid A analogues were rationally designed through MD-2 docking studies. A ...
Toll-like receptor (TLR) stimulation has been implicated as amajor contributor to chronic inflammati...
AbstractA literature review concerning the unexpected species differences of the vertebrate innate i...
The best-characterized Toll-like receptor 4 (TLR4) ligands are lipopolysaccharide (LPS) and its chem...
Previous high throughput screening studies led to the discovery of two novel, nonlipid-like chemotyp...