Mantle plumes are typically considered secondary features of mantle convection, yet their surface effects over Earth's evolution may have been significant. We use 2-D convection models to show that mantle plumes can in fact cause the termination of a subduction zone. This extreme case of plume-slab interaction is found when the slab is readily weakened, e.g. by damage-type rheology, and the subducting slab is young. We posit that this mechanism may be relevant particularly for the early Earth, and more generally, plume "talk back" to subduction zones may make plate tectonics more episodic in certain cases. When these models are carried out in a 3-D geometry, we see the same plume-slab terminations take place and can observe the effect of la...