The discovery of the Higgs boson in 2012 at CERN completed the experimental confirmation of the Standard Model particle spectrum. Current theoretical insights and experimental data are inconclusive concerning the expectation of future discoveries. While new physics may still be within reach of the LHC or one of its successor experiments, it is also possible that the mass of particles beyond those of the Standard Model is far beyond the energy reach of any conceivable particle collider. We thus have to face the possibility that the age of “on-shell discoveries” of new particles may belong to the past and that we may soon witness a change in the scientists' perception of discoveries in fundamental physics. This article discusses the relevance...