Few single nucleotide polymorphisms (SNPs) have been reproducibly associated with hepatocellular carcinoma (HCC). Our aim was to test the association between nine SNPs and HCC occurrence. SNPs in genes linked to HCC (DEPDC5, GRIK1, KIF1B, STAT4, MICA, DLC1, DDX18) or to liver damage (PNPLA3-rs738409, TM6SF2-rs58542926) in GWAS were genotyped in discovery cohorts including 1,020 HCC, 2,021 controls with chronic liver disease and 2,484 healthy individuals and replication was performed in prospective cohorts of cirrhotic patients with alcoholic liver disease (ALD, n = 249) and hepatitis C (n = 268). In the discovery cohort, PNPLA3 and TM6SF2 SNPs were associated with HCC (OR = 1.67 [CI95%:1.16-2.40], p = 0.005; OR = 1.45 [CI95%:1.08-1.94], p =...
BACKGROUND & AIMS Subtle inter-patient genetic variation and environmental factors combine to det...
BACKGROUND AND AIM: The PNPLA3 rs738409 C>G polymorphism has been found to be strongly associated wi...
Hepatocellular carcinoma (HCC) has one of the worst prognoses amongst all malignancies. It commonly ...
Few single nucleotide polymorphisms (SNPs) have been reproducibly associated with hepatocellular car...
Few single nucleotide polymorphisms (SNPs) have been reproducibly associated with hepatocellular car...
BACKGROUND: PNPLA3 rs738409 polymorphism is associated with fatty liver disease, alcoholic or non-a...
The incidence of hepatocellular carcinoma (HCC) is increasing in Western countries. Although several...
The incidence of hepatocellular carcinoma (HCC) is increasing in Western countries. Although several...
The incidence of hepatocellular carcinoma (HCC) is increasing in Western countries. Although several...
Variants in patatin-like phospholipase domain-containing 3 (PNPLA3; rs738409), transmembrane 6 super...
OBJECTIVES Variants in patatin-like phospholipase domain-containing 3 (PNPLA3; rs738409), transmemb...
BACKGROUND: An isoleucine>methionine mutation at position 148 in the PNPLA3 gene (p.I148M, rs738409)...
Background: An isoleucine.methionine mutation at position 148 in the PNPLA3 gene (p.I148M, rs738409)...
Background & Aims : Recently, the Patatin-like phospholipase domain-containing 3 (PNPLA3) rs738409 C...
Hepatocellular carcinoma (HCC) is among the most prevalent and lethal cancers worldwide. In the sett...
BACKGROUND & AIMS Subtle inter-patient genetic variation and environmental factors combine to det...
BACKGROUND AND AIM: The PNPLA3 rs738409 C>G polymorphism has been found to be strongly associated wi...
Hepatocellular carcinoma (HCC) has one of the worst prognoses amongst all malignancies. It commonly ...
Few single nucleotide polymorphisms (SNPs) have been reproducibly associated with hepatocellular car...
Few single nucleotide polymorphisms (SNPs) have been reproducibly associated with hepatocellular car...
BACKGROUND: PNPLA3 rs738409 polymorphism is associated with fatty liver disease, alcoholic or non-a...
The incidence of hepatocellular carcinoma (HCC) is increasing in Western countries. Although several...
The incidence of hepatocellular carcinoma (HCC) is increasing in Western countries. Although several...
The incidence of hepatocellular carcinoma (HCC) is increasing in Western countries. Although several...
Variants in patatin-like phospholipase domain-containing 3 (PNPLA3; rs738409), transmembrane 6 super...
OBJECTIVES Variants in patatin-like phospholipase domain-containing 3 (PNPLA3; rs738409), transmemb...
BACKGROUND: An isoleucine>methionine mutation at position 148 in the PNPLA3 gene (p.I148M, rs738409)...
Background: An isoleucine.methionine mutation at position 148 in the PNPLA3 gene (p.I148M, rs738409)...
Background & Aims : Recently, the Patatin-like phospholipase domain-containing 3 (PNPLA3) rs738409 C...
Hepatocellular carcinoma (HCC) is among the most prevalent and lethal cancers worldwide. In the sett...
BACKGROUND & AIMS Subtle inter-patient genetic variation and environmental factors combine to det...
BACKGROUND AND AIM: The PNPLA3 rs738409 C>G polymorphism has been found to be strongly associated wi...
Hepatocellular carcinoma (HCC) has one of the worst prognoses amongst all malignancies. It commonly ...