Anticancer effect of Caesalpinia sappan by downregulating mitochondrial genes on A549 lung cancer cell line

Figure 1. Anticancer activity of Caesalpinia sappan against A549 cells line: (A) Cytotoxicity assay; (B) apoptosis assay; (C) cell cycle assay; (D) BAX-BCL-2 assay; (E) cell morphology microcopies. Figure 2. Gene expression profile of A549 cells after Caesalpinia sappan extract treatment for 24 h: (A) Pearson correlation; (B) Co-expression Venn diagrams; (C) Gene expression distribution; (D) heatmap analysis. Figure 3. Gene expression profile affects the biological processes of A549 cells after C. sappan extract treatment for 24 h: (A) Volcano plot; (B) biological processes for sixfold upregulation; (C) biological processes for sixfold up- and downregulation; (D) biological processes for sixfold downregulation. Figure 4. Protein interactions related to cancer on A549 cells after C. sappan extract treatment for 24 h. The red mark for gene found upregulated or downregulated in the A549 cells after treatment with the extract; (A): 6-fold upregulate; (B): 6-fold downregulat