Domperidone Nasal Gel Using Fenugreek Seed as Mucoadhesive Agent: Water Solubility Problem Sort-Out

Objective: The aim of this research work was to develop a mucoadhesive nasal gel of domperidone in an aqueous medium. Mixed solvency concept was used to enhance the aqueous solubility of Domperidone. Methods: The study was facilitated by collecting fenugreek seeds and subjected to hydro extraction. Mixed solvency concept was used to improve aqueous solubility of domperidone. Results: Mucoadhesive agent was extracted from fenugreek seeds by simple hydro extraction. Solubility of domperidone was enhanced by using sodium citrate, urea, glycerine, PVP, PEG, propylene glycol, individually and in combinations. Maximum solubility was found in aqueous solution of PVP K 25 (4400.54μg/ml), PVP K 30 (4700.12μg/ml), PVP K 25 + PEG 600 (2202.24μg/ml), PVP K 30 + PEG 600 (2306.92μg/ml), PVP K 30 + PEG 1540 (2288.66μg/ml), PVP K 25 + PEG 400 (2396.22μg/ml), PVP K 25 + PEG 600 (2455.18μg/ml), PVP K 25 + Propylene glycol (2378.24μg/ml), PVP K 30 + PEG 400 (2628.45μg/ml), PVP K 30 + PEG 600 (2698.76μg/ml), PVP K 30 + Propylene glycol (2604.22μg/ml). Conclusion: Mucoadhesive properties were provided by using fenugreek seed extract. Mucoadhesive agent extracted from fenugreek seed was observed more viscous than synthetic polymer, i.e., HPMC, Carbopol. Domperidone solubility was enhanced by using various solid and liquid solubilizers individually as well as in combination. In future domperidone nasal gel may be used for the treatment of gastro paresis, nausea, vomiting and replace other conventional dosage forms