Cancer research has demonstrated that immunization with homologous xenogeneic proteins (such as vaccines contaminated with animal proteins that resemble human proteins) results in autoimmunity. Bioinformatics analysis demonstrates that animal proteins have occasional amino acids differences compared to equivalent human proteins. So mutated human protein epitopes can be identical to animal protein derived epitopes. Low affinity self reactive T cells suited for detection of mutated human epitopes will be activated by animal derived epitopes. CD8+ T cells involved in numerous autoimmune disorders express the CCR4 skin homing receptor. This is evidence that the site of priming was the skin. This is consistent with subcutaneous or intramuscular...
Rheumatoid arthritis (RA) is an autoimmune disorder. Rheumatoid factor (RF) and anti- citrullinated ...
Our research group has developed a new vaccination technique in experimental animals that has the po...
The notion that mimicry between a self and a microbial peptide antigen can trigger or aggravate auto...
Cancer research has demonstrated that immunization with homologous xenogeneic proteins (such as vacc...
© 2018, Pharmainfo Publications. All rights reserved. Cancer research has demonstrated that immuniza...
Thymocytes with T cell receptors (TCR) that have high affinity for self peptides are usually negativ...
Myasthenia Gravis (MG) is a neuromuscular junction disorder. It is caused by antibodies directed aga...
The National Institute of Allergy and Infectious Diseases (NIAID) sponsors the Immune Epitope Data B...
Autoimmune diseases are initiated when patients develop aberrant T and/or B cell responses against s...
Case reports implicate influenza, tetanus, diphtheria, and pertussis (Tdap), human papilloma virus, ...
The human papillomavirus (HPV) vaccine and Hepatitis B vaccine (HBV) are recombinant vaccines produc...
Autoimmune diseases are initiated when patients develop aberrant T and/or B cell responses against s...
The skin is a component of the immune system. At a conceptual level, food antigen exposure to damage...
The paradigm for pathogenic autoimmunity is the generation of high-titre, affinity-matured autoantib...
Molecular mimicry of viral antigens with self determinants has been proposed as one of the pathogeni...
Rheumatoid arthritis (RA) is an autoimmune disorder. Rheumatoid factor (RF) and anti- citrullinated ...
Our research group has developed a new vaccination technique in experimental animals that has the po...
The notion that mimicry between a self and a microbial peptide antigen can trigger or aggravate auto...
Cancer research has demonstrated that immunization with homologous xenogeneic proteins (such as vacc...
© 2018, Pharmainfo Publications. All rights reserved. Cancer research has demonstrated that immuniza...
Thymocytes with T cell receptors (TCR) that have high affinity for self peptides are usually negativ...
Myasthenia Gravis (MG) is a neuromuscular junction disorder. It is caused by antibodies directed aga...
The National Institute of Allergy and Infectious Diseases (NIAID) sponsors the Immune Epitope Data B...
Autoimmune diseases are initiated when patients develop aberrant T and/or B cell responses against s...
Case reports implicate influenza, tetanus, diphtheria, and pertussis (Tdap), human papilloma virus, ...
The human papillomavirus (HPV) vaccine and Hepatitis B vaccine (HBV) are recombinant vaccines produc...
Autoimmune diseases are initiated when patients develop aberrant T and/or B cell responses against s...
The skin is a component of the immune system. At a conceptual level, food antigen exposure to damage...
The paradigm for pathogenic autoimmunity is the generation of high-titre, affinity-matured autoantib...
Molecular mimicry of viral antigens with self determinants has been proposed as one of the pathogeni...
Rheumatoid arthritis (RA) is an autoimmune disorder. Rheumatoid factor (RF) and anti- citrullinated ...
Our research group has developed a new vaccination technique in experimental animals that has the po...
The notion that mimicry between a self and a microbial peptide antigen can trigger or aggravate auto...