ANIMAL WOUND HEALING MODELS IN EXPERIMENTAL PHARMACOLOGY

This study investigates several models of animal wound healing utilized in experimental pharmacology. A substantial quantity of material has been produced on wound healing models. However, there is limited research on the selection of animal species, animal weight, animal age, animal gender, methods of wound formation, and the benefits and limits of wound models. The paper describes in detail the various animals used to create wound models, their characteristics and features; the characteristics of each model; the scope of each model; and the application of each model in various types of testing, including suture materials, drugs, peptides, dressing materials, artificial skin substitutes, topical agents, antimicrobials, nano-dressing materials, functionalized and genetically engineered biomaterials, etc. Animal wound healing is widely replicated in order to comprehend the mechanics of wound restoration. In wound healing research, the choice of models depends on a number of factors, like : the type of exploration, such as cell regeneration biology or aetiopathogenesis; medicinal product efficacy; dressing effectiveness; safety assessment, pharmacokinetic properties, etc.); the type of approach (in vitro ( cultured cells) or vivo, acute model/impaired model/foetal tissue repair , animal models/human models , etc.); vertebrate animals or human research (mammal type, anatomical structures, physiology, generalisation, ethical concerns, etc.); and (age of animal , species of animal, species of animal , wild or transgenic, statistical consideration, etc.). In this study, many models are looked at in terms of: type of strain; weight; age; gender; wound size, depth, and type; instruments used; production method; wound model application; and pros and cons for each model