Quantitative structure activity relationship studies on a series of 4-pyridones as antimalerial agents

Department of Applied Sciences, NITTTR, Shamla Hills, Bhopal-462 002, Madhya Pradesh, India E-mail : basheerulla.81@gmail.com Department of Chemistry, Technocrats Institute of Technology and Science, Bhopal, Madhya Pradesh, India Department of Chemistry, A. P. S. University, Rewa-486 003, Madhya Pradesh, India E-mail : apsvka@yahoo.co.in Quantitative structure-activity relationship (QSAR) studies have been performed on a series of twenty four (24) 4-pyridone analogues as antimalarial agents. A genetic algorithm multiple linear regression (GA-MLR) analysis has shown that three-variable model containing 2xv, SpMin8_Bh(s), CATS2D_06_DL, is best for modelling the compounds used in the present study. Using the GA-MLR model, some new compounds have also been proposed which show higher potency