Pectin as a Versatile Biodegradable Polymer

An investigation has been undertaken to assess, in vitro, the potential of several pectin formulations as a versatile polymer in various drug delivery systems. Literature review was studied on the release of model compounds from various drug delivery systems under conditions pertaining to those in vivo. The monitoring of release gives a sensitive indication of the behavior of the pectin under the different conditions. The type of pectin, the presence of calcium and the solubility of the calcium salt all influence release. Additionally, pectins with a low degree of methoxylation were more susceptible to enzymatic breakdown. Calcium enhanced the enzymatic activity. Rheological studies indicate that gel strength was a factor in determining release. This suggested that either a high methoxy pectin formulation or a low methoxy pectin with a carefully controlled amount of calcium should maximize colonies specificity by providing optimal protection of a drug during its transit to the colon and a high susceptibility to enzymic attack. On the other hand, this may also enhance mucoadhesive contributing in favor of other oral dosage forms