Management of Mild and Moderate Symptoms of COVID-19 in Infected Subjects using Combi-5 Herbal Supplement: Case Series

ABSTRACT Corona virus Diseases 2019 (COVID-19) has caused significant distortion globally. Concerted efforts are being made to develop treatments including vaccines, however, emerging of new strains of the virus, high cost of available treatments, distortion in global distribution of available vaccines and vaccine hesitancy require that accessible, cheaper and complimentary treatment be explored and developed. This report is aimed to explore the use of Combi-5 herbal supplement in managing subjects with mild and moderate symptoms of COVID-19. We present case series of two subjects who tested positive for COVID-19 with mild and moderate symptoms , self-managed at home using Combi-5 herbal supplement taken along with vitamin C and Zinc. Both subjects recovered and did not require further medical admission. Phytochemical constituents of herbal supplement were measured using standard methods. Concomitant use of Combi-5 herbal supplement, zinc and vitamin C could improve prognosis in COVID 19 positive subjects with mild and moderate symptoms. Future studies using Combi-5 should be focused on performing detailed molecular docking, in-vitro SARS-CoV-2 enzyme inhibition experiment and conducting randomized controlled trial to validate the clinical observation