Data for "Predicting In-depth mechanisms of action for cancer drugs." Please download these files and put them in a folder named "Data". Download the respective scripts from https://github.com/ruppinlab/drug.OnTargetFile Description: onTarget (onTarget_v3.0.RDS): A single object is a curation of all the DepMap data including viability screens after CRISPR-Cas9 & drug treatment, expression & mutation of cell lines. KnowTraget_prediction (KnownTarget_predictions_v4.RDS): Metadata of Drugs and their target+DeepTarget's top predicted target information drugVScrispr_corr_features_list (drugVScrispr_corr_features_list.RDS): DKS Score & P for each gene vs each drug. drugVScrispr_corr_features_list_secondary (drugVScrispr_corr_features_list_seconda...
This record contains the checkpoint for a Chemprop model trained to predict the probability that a m...
A major cause of failed drug discovery programs is suboptimal target selection, resulting in the dev...
Many drugs exert their therapeutic activities through the modulation of multiple targets. Moreover, ...
Data for "Predicting In-depth mechanisms of action for cancer drugs." Please download these files an...
This repository contains preprocessed data files and trained model files associated with the manuscr...
This repository contains preprocessed data files, trained model files, and SHAP results associated w...
Motivation: Chemotherapy or targeted therapy are two of the main treatment options for many types of...
These are output files of shared R scripts used in prediction of repurposed drugs for treating lung ...
In the era of precision medicine, cancer therapy can be tailored to an individual patient based on t...
Chemotherapeutic response of cancer cells to a given compound is one of the most fundamental informa...
Screening new drug-target interactions (DTIs) by traditional experimental methods is costly and time...
Motivation: Accurate and robust drug response prediction is of utmost importance in the realm of pre...
## GDSC dataset **GDSC_EXP.csv** GDSC gene expression profiles for 966 cancer cell lines, where eac...
Increasing incidence of numerous forms of cancer leads it to be the deadliest disease globally. Hen...
A key goal of precision medicine is predicting the best drug therapy for a specific patient from gen...
This record contains the checkpoint for a Chemprop model trained to predict the probability that a m...
A major cause of failed drug discovery programs is suboptimal target selection, resulting in the dev...
Many drugs exert their therapeutic activities through the modulation of multiple targets. Moreover, ...
Data for "Predicting In-depth mechanisms of action for cancer drugs." Please download these files an...
This repository contains preprocessed data files and trained model files associated with the manuscr...
This repository contains preprocessed data files, trained model files, and SHAP results associated w...
Motivation: Chemotherapy or targeted therapy are two of the main treatment options for many types of...
These are output files of shared R scripts used in prediction of repurposed drugs for treating lung ...
In the era of precision medicine, cancer therapy can be tailored to an individual patient based on t...
Chemotherapeutic response of cancer cells to a given compound is one of the most fundamental informa...
Screening new drug-target interactions (DTIs) by traditional experimental methods is costly and time...
Motivation: Accurate and robust drug response prediction is of utmost importance in the realm of pre...
## GDSC dataset **GDSC_EXP.csv** GDSC gene expression profiles for 966 cancer cell lines, where eac...
Increasing incidence of numerous forms of cancer leads it to be the deadliest disease globally. Hen...
A key goal of precision medicine is predicting the best drug therapy for a specific patient from gen...
This record contains the checkpoint for a Chemprop model trained to predict the probability that a m...
A major cause of failed drug discovery programs is suboptimal target selection, resulting in the dev...
Many drugs exert their therapeutic activities through the modulation of multiple targets. Moreover, ...