Compared with many normal tissues, cancer cells are highly sensitized to apoptotic signals, and survive only because they have acquired lesions - such as loss of p53 - that prevent or impede cell death. We are now beginning to understand the complex mechanisms that regulate whether or not a cell dies in response to p53 - insights that will ultimately contribute to the development of therapeutic strategies to repair the apoptotic p53 response in cancers
Programmed cell death was a fundamental discovery, awarded with the Nobel price in 2002 to Sulston, ...
The p53 tumor suppressor acts to integrate multiple stress signals into a series of diverse antiprol...
Programmed cell death was a fundamental discovery, awarded with the Nobel price in 2002 to Sulston, ...
Compared with many normal tissues, cancer cells are highly sensitized to apoptotic signals, and surv...
p53 is frequently mutated in cancer and as a result is one of the most intensely studied tumour supp...
The p53 tumour suppressor is best known for its canonical role as “guardian of the genome”, activati...
The p53 tumor suppressor protein acts as a major defense against cancer. Among its most distinctive ...
It is widely stated that wild-type p53 either mediates the activation of cell cycle checkpoints to f...
P53 is known as the most critical tumor suppressor and is often referred to as the guardian of our g...
Many chemotherapeutic drugs kill only a fraction of cancer cells, limiting their efficacy. We used l...
p53, a tumor suppressor and transcription factor, is a critical mediator of the cellular response to...
p53, a tumor suppressor and transcription factor, is a critical mediator of the cellular response to...
Many chemotherapeutic drugs kill only a fraction of cancer cells, limiting their efficacy. We used l...
Programmed cell death was a fundamental discovery, awarded with the Nobel price in 2002 to Sulston, ...
Programmed cell death was a fundamental discovery, awarded with the Nobel price in 2002 to Sulston, ...
Programmed cell death was a fundamental discovery, awarded with the Nobel price in 2002 to Sulston, ...
The p53 tumor suppressor acts to integrate multiple stress signals into a series of diverse antiprol...
Programmed cell death was a fundamental discovery, awarded with the Nobel price in 2002 to Sulston, ...
Compared with many normal tissues, cancer cells are highly sensitized to apoptotic signals, and surv...
p53 is frequently mutated in cancer and as a result is one of the most intensely studied tumour supp...
The p53 tumour suppressor is best known for its canonical role as “guardian of the genome”, activati...
The p53 tumor suppressor protein acts as a major defense against cancer. Among its most distinctive ...
It is widely stated that wild-type p53 either mediates the activation of cell cycle checkpoints to f...
P53 is known as the most critical tumor suppressor and is often referred to as the guardian of our g...
Many chemotherapeutic drugs kill only a fraction of cancer cells, limiting their efficacy. We used l...
p53, a tumor suppressor and transcription factor, is a critical mediator of the cellular response to...
p53, a tumor suppressor and transcription factor, is a critical mediator of the cellular response to...
Many chemotherapeutic drugs kill only a fraction of cancer cells, limiting their efficacy. We used l...
Programmed cell death was a fundamental discovery, awarded with the Nobel price in 2002 to Sulston, ...
Programmed cell death was a fundamental discovery, awarded with the Nobel price in 2002 to Sulston, ...
Programmed cell death was a fundamental discovery, awarded with the Nobel price in 2002 to Sulston, ...
The p53 tumor suppressor acts to integrate multiple stress signals into a series of diverse antiprol...
Programmed cell death was a fundamental discovery, awarded with the Nobel price in 2002 to Sulston, ...
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