ISOLATION, SCREENING AND PRODUCTION OF (PRODIGIOSIN) NOVEL DRUG FROM MARINE SEDIMENTS

Serratia marcescensis a motile, short rod-shaped, Gram-negative, facultative anaerobic bacterium. It is commonly found in the moist regions of coastal areas and grows in room temperature at pH 5-9. S. marcescens is noted for production of secondary metabolites called prodigiosin, a bioactive compound having antibacterial, antifungal, anti-neoplastic, anti-proliferative, anti-oxidant and anti-malarial properties.Inthe present investigation, the marine sediment samples were collected from Gulf of Mannar, Mandapam coast. The samples were serially diluted and spread plated on Nutrient agar medium to isolate the efficient prodigiosin producing bacteria. The efficient prodigiosin producing bacteria was identified as Serratia marcescens based on morphological and biochemical characterization methods. Optimization studies production of prodigiosin by S.marcescens is influenced by numerous factors such as inorganic phosphate availability, medium composition, temperature, pH, and natural components. The production of prodigiosin were extract, estimate and partially purified (crude) prodigiosin was used as a antimicrobial, anti-fungal, Anti-inflammatory and dyeing effect was carried out. Specially, it has an inhibiting and destructive effect on the production and stability of prodigiosin. FTIR analysis were studied. The prodigiosin has known define role in the physiology of the strains in which it is produced, it has antifungal, antibacterial and antiprotozoal activities, and thus may have potential clinical utility