IMPACT OF HORMONE RECEPTOR STATUS (ER, PR, HER-2) ON PATTERNS OF METASTASIS IN BREAST CANCER AND ITS PHARMACEUTICAL MANAGEMENT IN TERTIARY CARE HOSPITAL: A PROSPECTIVE OBSERVATIONAL STUDY

Despite the progress that has been made in diagnosis and treatment of early stage breast cancer a substantial proportion of patients still go on to develop incurable distant metastatic cancer. Estrogen receptors, progesterone receptors, human epidermal receptor-2 expression in breast cancer are associated with development of distant metastases. Most commonly observed site for distant metastases are liver, lung, bone, brain. The purpose of present study is to examine the hormone receptor status on development of distant metastases (liver, lung, bone, brain). The purpose of the present study focused mainly impact of hormone receptors such as estrogen receptor, progesterone receptor and human epidermal growth factor receptors in metastatic breast cancer were distant organs involved were liver, lung, bone, brain, recurrence and its pharmaceutical management based on receptor status in a tertiary care hospital. Based on the receptor presence and absence the treatment alters. Hence it is necessary to study the hormone receptor status which helps in management of disease and to prevent further progression of disease. Key words:metastatic breast cancer, hormone receptor status, estrogenreceptor(ER), progesterone receptor(PR), human epidermal receptor-2(HER2)