FORMULATION AND EVALUATION OF CARVEDILOL SUBLINGUAL TABLET

Carvedilol is an oral antihypertensive agent. Due to its poor water solubility it posses problems of variable bioavailability and bioequivalence. In the present work an attempt was done to develop sublingual tablets of carvedilol using different superdisintegrants like crosscarmellose sodium, crosspovidone and sodium starch glycolate in different ratios. As carvedilol is a poor soluble drug the solubility was enhanced by solid dispersion method. Tablets were prepared by direct compression technique. Prepared tablets were evaluated for thickness, uniformity of weight, hardness, friability, wetting time, in-vitro disintegration time, drug content and in vitro drug release. All the formulations were evaluated for the characteristics of sublingual tablets mainly in terms of .disintegration time and dissolution studies .Out of the 7 formulation, formulation F7 shows the maximum drug release. The formulation F7 consist of super disintegrant crosscarmellose sodium 5% and drug polymer in the ratio 1:4.From the literature it was evident that drug release was increased with increase in concentration of the polymer. So the formulation F7 was optimized as the best formulation. Keywords: Carvedilol, Sublingual tablet, Super disintegrants, Bioavailabilit