The Effectiveness Comparison of Aloe Vera and Nothopanax Sutellarium Extract Toward Thermal Burn on White Rat (Rattus Norvegicus)

Nasution Sri Lestari Ramadhani, Revina Monica, Yuliani Riski, Nasution Sri Wahyuni. The Effectiveness Comparison of Aloe Vera and Nothopanax Sutellarium Extract Toward Thermal Burn on White Rat (Rattus Norvegicus). Journal of Education, Health and Sport. 2019;9(4):580-590. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.2653313 http://ojs.ukw.edu.pl/index.php/johs/article/view/6869 https://pbn.nauka.gov.pl/sedno-webapp/works/912278 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26/01/2017). 1223 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Authors 2019; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 15.04.2019. Revised: 25.04.2019. Accepted: 29.04.2019. The Effectiveness Comparison of Aloe Vera and Nothopanax Sutellarium Extract Toward Thermal Burn on White Rat (Rattus Norvegicus) Sri Lestari Ramadhani Nasution*1, Monica Revina2, Riski Yuliani3, Sri Wahyuni Nasution4 *Corresponding author 1Public Health Faculty, Medical Faculty, Prima Indonesia University, Medan, Indonesia 2 Medical Faculty, Prima Indonesia University, Medan, Indonesia 3 Medical Faculty, Prima Indonesia University, Medan, Indonesia 4Department Tropical Medicine, Medical Faculty, Prima Indonesia University, Medan, Indonesia Abstract Thermal burn is depicted as tissue damage which is caused by heat contact, chemical material, electricity and radiation. Several herbal materials that can be used as burn healing are Aloe Vera and Nothopanax Scutellarium. This study is aimed to find out the effectiveness comparison between 50% and 70% concentration on each herbal materials. The sample that used is 30 white rats (Rattus Norvegicus) which is chosen according to the inclusion criteria, and will be divided into 6 groups in which each of groups are given different treatment including: positive control, negative control, 50% formulation of N. scutellarium extract ointment, 75% N. scutellarium, and 50% A. vera. The extract formulation is obtained using maceration method using 96% ethanol solvent, and then the extract will be formulated to be A. vera extract ointment and N. scutellarium with 50% and 75% concentration. The withe rats which given thermal burn treatment will be applied using ointment extract, and it will be left out and observed every three days. Afterward, from the results, the significant will be assessed using ANOVA method. Thus, the results show that A. vera has p = 0,045 and N. scutellarium has p = 0,038 and for both of them are p < 0,05. The T significance then assessed by the result of A. vera extract and N. Scutellarium are p = 0,000 and p < 0,005, respectively. Hence, from the result of assay, the smallest level of burn severity is on N. scutellarium extract, therefore it can be said as the most effective for wound healing with 75 % concentration than A. vera. Keywords: aloe vera, Nothopanax Sutellarium, thermal burn, ointment