Therapeutic Potential of Methanolic Chicory Leaves Extract Against H2O2-Induced Hepatotoxicity in Rats

Liver diseases have become a major global health challenge and may be triggered by several toxic chemicals, which include chemotherapeutic agents, thioacetamide, H2O2, certain antibiotics, excessive alcohol consumption, and pathogenic microbes. Hence, safeguarding a healthy liver is vital for good health and well-being. Chicory (Cichorium intybus) belongs to Asteraceae Family and is considered very important medicinal plant in this direction. The present study deals evaluation methanolic extracts of Chicory plant for a period of 45 days at the following dose levels; 50 and 75 mg/kg body weight/day, orally respectively. The activities were studied by assaying aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), total and direct bilirubin (TB)and (DB), total protein (TP), albumin (Alb), catalase (CAT) and Superoxide dismutases (SOD). The methanolic extract of Cichorium intybus at dose 75 mg/kg body weight/day has the highest effectiveness against H2O2- induced hepatotoxicity