A novel and facile environmentally benign oxidative electrocyclization of acylthiosemicarbazone into biodynamic 1,3,4-oxadiazoles

Electrochemical Laboratory of Green Synthesis, Department of Chemistry, University of Allahabad, Allahabad-211002, Uttar Pradesh. India E-mail : rkp.singh@rediffmail.com . Manuscript received 01 November 2010, accepted 02 November 2010 A novel, facile and green oxidative electrocyclization of the acylthiosemicarbazone into 5-suhstiluted-2- amino(substituted)-1 ,3.4-oxadiuzoles at platinum electrode using acetonitrile as non-aqueous solvent and lithium perchlorate as supporting electrolyte at an apparent current density of 4-6 F/mol is described. The electrooxidative cyclization was carried out under controlled potential electrolysis in an undivided cell. The reaction was smooth and quantitative with excellent yield. The antifungal screening of the synthesized compounds was also done against Alternaria solani, hisaritan oxisportan-uduni and Aspergillus niger species