Pathophysiological analysis of systemic and renal disregulation of pathological processes in the damage of proximal tubule in the nephrolithiasis

Rohovyi Yurii, Ariychuk Oleksandr. Pathophysiological analysis of systemic and renal disregulation of pathological processes in the damage of proximal tubule in the nephrolithiasis. Journal of Education, Health and Sport. 2019;9(3):641-651. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.3460960 http://ojs.ukw.edu.pl/index.php/johs/article/view/7528 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26/01/2017). 1223 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Authors 2019; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 11.03.2019. Revised: 22.03.2019. Accepted: 29.03.2019. UDC 616.633.962.4-02: 616.613-003.7-089.879 PATHOPHYSIOLOGICAL ANALYSIS OF SYSTEMIC AND RENAL DISREGULATION OF PATHOLOGICAL PROCESSES IN THE DAMAGE OF PROXIMAL TUBULE IN THE Nephrolithiasis Yurii Rohovyi1, Oleksandr Ariychuk2 1State Educational Establishment of Ukraine “Bukovinian State Medical University”,Chernivtsi, Ukraine Chief of the department pathological physiology the higher 2Regional Clinical Institution “Hospital of emergency medical care” in “Center of endourology and lithotripsy”, st. Fastiv, 2, Chernivtsi, Ukraine Doctor-urologist Abstract The pathogenesis of urolithiasis in the modern view lies disregulating the pathological process of primary surplus mobilization reactions of protection, which leads to their further transformation in the reaction of damage that is the underlying basis for the formation of vicious circles. 299 patients with nephrolithiasis were examined, 10 patients were in the control group. Found that systemic and renal dysregulation pathological processes of stone the size of stones of 0.6 – 1.0 cm, top, middle cup the upper third of the ureter led to the formation of large and small “vicious circles”. Renal and extrarenal dysregulation pathological processes contributed to the increase in damage to the proximal tubule, since the primary damage to the said nephron. Department is not able to mobilize protective adaptive reactions aimed at increasing the excretion of acids and protein reabsorption, since they require additional energy costs. The use of the drug blemaren in nephrolithiasis reveals protective properties to reduce the manifestations of systemic and renal dysregulation pathological processes and promotes the rupture of formed large and small “vicious circles" with a decrease in proteinuria, the level of tumor necrosis factor-α, improving the transport of sodium ions, fibrinolytic activity of urine and it is advisable to develop guidelines for further use in the clinic of the drug blemaren as a promising method of treatment of urolithiasis. Key words: nephrolithiasis, systemic and renal dysregulation processes, large and small vicious circles, proximal tubular injury, blemaren