Single cell transcriptomes of of primary tumors and normal endometrial derived organoids treated with DBZ

Endometrial carcinoma, the most common gynecologic cancer, develops from endometrial epithelium which is composed of secretory and ciliated cells. Pathologic classification is unreliable and there is a need for prognostic tools. We used single cell sequencing to study organoid model systems derived from normal endometrial endometrium to discover novel markers specific for endometrial ciliated or secretory cells. We performed 10X based single cell sequencing on both normal and DBZ treated organoids, and on endometrial and ovarian tumours.This work was supported by the Canadian Cancer Society Research Initiative Impact Grant. We also wish to acknowledge further support from the BC Cancer Foundation and the VGH and UBC Hospital Foundations