Abstract Despite the growing interest by researchers into cellular senescence, a hallmark of cellular aging, its role in human skin remains equivocal. The skin is the largest and most accessible human organ, reacting to the external and internal environment. Hence, it is an organ of choice to investigate cellular senescence and to target root-cause aging processes using senolytic and senomorphic agents, including naturally occurring plant-based derivatives. This review presents different aspects of skin cellular senescence, from physiology to pathology and signaling pathways. Cellular senescence can have both beneficial and detrimental effects on the skin, indicating that both prosenescent and antisenescent therapies may be desirable, base...
Aging is a complex process characterized by an ongoing decline in physiological functions, leading ...
Skin is the largest organ of the body with important protective functions, which become compromised ...
Organismal ageing is a complex process driving progressive impairment of functionality and regenerat...
Senescent cells are induced by a wide variety of stimuli. They accumulate in several tissues during ...
Senescent cells are induced by a wide variety of stimuli. They accumulate in several tissues during ...
Cellular senescence is an irreversible growth arrest that occurs as a result of different damaging s...
Chronic exposure to UVR is known to disrupt tissue homeostasis, accelerate the onset of age-related ...
Skin is the largest human organ system, and its protective function is critical to survival. The epi...
Higher organisms contain two types of cells: postmitotic cells, which never divide, and mitotic (or ...
Cellular senescence, a process that imposes permanent proliferative arrest on cells in response to v...
Cellular senescence is a complex and multistep biological process which cells can undergo in respons...
Cellular senescence is an irreversible growth arrest that occurs as a result of different damaging s...
Aging is a complex process characterized by an ongoing decline in physiological functions, leading t...
The skin is the body's largest organ and it is able to self-repair throughout an individual's life. ...
Cellular senescence is a state of stable cell cycle arrest associated with macromolecular alteration...
Aging is a complex process characterized by an ongoing decline in physiological functions, leading ...
Skin is the largest organ of the body with important protective functions, which become compromised ...
Organismal ageing is a complex process driving progressive impairment of functionality and regenerat...
Senescent cells are induced by a wide variety of stimuli. They accumulate in several tissues during ...
Senescent cells are induced by a wide variety of stimuli. They accumulate in several tissues during ...
Cellular senescence is an irreversible growth arrest that occurs as a result of different damaging s...
Chronic exposure to UVR is known to disrupt tissue homeostasis, accelerate the onset of age-related ...
Skin is the largest human organ system, and its protective function is critical to survival. The epi...
Higher organisms contain two types of cells: postmitotic cells, which never divide, and mitotic (or ...
Cellular senescence, a process that imposes permanent proliferative arrest on cells in response to v...
Cellular senescence is a complex and multistep biological process which cells can undergo in respons...
Cellular senescence is an irreversible growth arrest that occurs as a result of different damaging s...
Aging is a complex process characterized by an ongoing decline in physiological functions, leading t...
The skin is the body's largest organ and it is able to self-repair throughout an individual's life. ...
Cellular senescence is a state of stable cell cycle arrest associated with macromolecular alteration...
Aging is a complex process characterized by an ongoing decline in physiological functions, leading ...
Skin is the largest organ of the body with important protective functions, which become compromised ...
Organismal ageing is a complex process driving progressive impairment of functionality and regenerat...