UNCERTAINTY OF RBE MODEL IN PROTON RADIOTHERAPY BASED ON α/β RATIO AND LINEAR ENERGY TRANSFER

The dataset includes data from in vitro experiments on 11 cell lines: V79-379A, V79-753B, DLD1, SQ20B, CI-1, C3H10T1/2, SCC25, HCT116, H184B5 F5-1M/10 and HF19 (folder „data”). These data were taken from the survival curves available in the source articles and then a linear-quadratic model was fitted to them , from which the α and β parameters were obtained (04_Distributions, Figure 1). All operations on the experimental data, their reading, preparation(01_PreaparingData.ipynb) and analysis (02_Fitting_LQmodel.ipynb) were performed in Jupyter Notebooks. The experimental database has been cleared of outliers based on several conditions(03_Outliers.ipynb). A comparison of biological dose (05_SOBP.ipynb , Figure 2) was set up on a depth-dose and LET profile („data/sobp_10mln”) as being used in radiobiological in vivo mouse experiments (folder „mc_simulation”). ACKNOWLEDGEMENTS K. Jeleń acknowledges the support of InterDokMed project No. POWR.03.02.00-00-I013/1