Heterocyclic Compounds. Part-IX Syntheses of N-Nitrosoureas and N-Nitrosothioureas as Possible Antitumor Agents

Department of Chemistry, Sambalpur University, Joyti Vihar, Burla, Sambalpur-768 017 The synthesis or several novel N-nitrosoureas and N-nitrosothioureas from various heterocyclic and alicyclic amines have been described. Nitrosoureas were prepared by nitrosation of ureas using NaNo2 in formic acid whereas nitrosothioureas were obtained by nitrosation of thioureas under slightly acidic condition. The higher acidic reaction condition of thioureas favoured nitrosation at more reactive sulphur leading to urea derivatives via thionitrosyl intermediate. The antitumor activity or some compounds has been evaluated against leukemia L1210