Synthesis, characterization and antibacterial screening of new pyrazole and pyrazoline-5-one derivatives

Department of Chemistry, Sri Krishnadevaraya University, Anantapur-515 003, Andhra Pradesh, India Department of Chemistry, Sri Krishnadevaraya University Post-Graduate Centre, Kurnool-518 002, Andhra Pradesh, India E-mail : ramanapv2103@yahoo.com Manuscript received 21 July 2009, revised 10 May 2010, accepted 07 July 2010 A series of N' -(p-toluene sulphonyl)-3-methyl-4-(substituted arylhydrazono)-2-pyrazoline-5-ones and N' -(2- hydroxybenzoyl)-3,5-dimethyl-4-(substituted arylazo)pyrazoles have been synthesized and characterized by chemical analysis, IR and 1H NMR spectral data. The compounds have been screened for antibacterial activity against Staphylococcus aureus and Escherichia coli