Effect of the drug Diclofenac on the brain tissue of Channa punctatus

Abstract Pharmaceuticals are the biologically active compounds that are designed to exert specific action on the target molecules of human and veterinary animals. The erroneous use of these drugs has resulted in aquatic pollution. Diclofenac is a non-steroidal anti- inflammatory drug that has been usually detected in surface waters worldwide. There are investigations on the toxicity of this drug in aquatic flora and fauna. The acute toxic studies on the histological alterations in fish are very rare. The brain is an important organ which controls all functions of the body. The freshwater fish, Channa punctatus, has been exposed to ten different concentrations of diclofenac for 96 hours. The median lethal concentration was found to be 25.28ppm. The fish were exposed to 8.42 ppm and 25.28 ppm concentrations of Diclofenac for 96 hours. 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