Management of status epilepticus in adults: PROTOCOL for a systematic review of clinical practice guidelines

The purpose of this protocol is to report the rationale and methodology of a systematic review of CPGs on the diagnostic and therapeutic management of SE in adults. The aims of this systematic review will be to 1) appraise the quality of CPGs, assuming that the Applicability domain may be particularly overlooked; 2) outline commonalities and discrepancies in recommendations; 3) highlight research gaps in the management of SE. This protocol is following the methodology suggested by Johnston et al. (Johnston et al., 2019) and is registered with PROSPERO database and published on the Zenodo repository and ResearchgateFunding from the Italian Ministry of Health (STatus EPilePticus in ER – STEPPER – bando 2016 Ricerca finalizzata ordinaria RF-2016-02361365