Conductance Behaviour of some associated Hydrochlorides of Medicinal Interest in Aqueous Solution at 298 K

Department of Chemistry, University of Kalyani, Kalyani-741 235 Manuscript received 12 April 1989, revised 19 September 1989, accepted 6 February 1990 The conductance studies of hydrochlorides of well-known druge (like pseudoephedrine, isoxsuprine, metoclopramide, pentazocine, propranalol, dicyclomine and ᴅʟ-phenylpropanolamine) in aqueous solutions have been made. The analysis of the results using Shedlovsky's equation indicates that the compounds are associated in aqueous solutions. Improved values of the association constants Kᴀ and Ʌo have been determined using Fuoss equation. The Ʌo values of the cations compare very well with those fortetraalkylammonium ions and it is expected that they undergo hydrophobicinteractions in aqueous solutions