Development and Characterization of Alpinia galanga-based Hydrogel: A Novel Approach for Antibacterial Therapeutics

Abstract: The burgeoning interest in natural and efficacious topical treatments has necessitated the exploration of plant-based bioactive compounds. This study aimed to formulate and assess a hydrogel enriched with Alpinia galanga extract, a plant renowned for its antibacterial and anti-inflammatory attributes. An exhaustive phytochemical analysis affirmed the existence of pivotal bioactive constituents in the extract. Three distinct hydrogel formulations (F1, F2, F3) were synthesized and rigorously evaluated based on pH, spreadability, viscosity, and in vitro drug release. The formulations exhibited optimal skin compatibility, favorable viscosity profiles, sustained drug release, and robust stability, thereby emerging as promising candidates for subsequent clinical investigations. This research not only offers a methodological blueprint for the development of plant-based hydrogels but also enriches the broader scientific discourse in pharmaceutical science and genetic toxicology