Short term effect of p-nonylphenol (p-NP) on serum metabolites of snake head fish, Ophiocephalus punctatus (Bloch, 1793)

ABSTRACT Surfactant p-NP found to affect the survival of snakehead fish, Ophiocephalus punctatus at LC-50. The organic metabolites such as protein, cholesterol and glucose showed significant changes during short term exposure to p-NP. All the organic metabolites in the serum were found increased significantly from the very first day to fourth day of exposure. This increase in the serum organic metabolites may be due to increase in the rate of metabolism in the liver. Increase in glucose indicates induction of glycogenolysis in the liver and increase in the cholesterol and protein could be due to endocrinal disruption. Key words: Nonylphenol, fish, organic metabolites REFERENCES A.E.H.Sayed, I.A.A. Mekkawy and U.M. Mahmoud, Afr. J.Biochem. Res., 2011, 5(9), 287-297. D.P.Khandale, N.A.Adbale, P.J.Khinchi and A.M.Chilke, Poll.Res.34(3), 119-122. G.M. Osman, M. Kautb and A.H.Sayed, 2010, J. Photoch. Photobio. B. 99, 1-8. Porika Raju and Estari Mamidala (2015). Anti-diabetic activity of compound isolated from Physalis angulata fruit extracts in alloxan induced diabetic rats. The Ame J Sci & Med Res, 2015,1(1); Pages 1 -6. doi:10.17812/ajsmr2015.11.1 I.A.A. Mekkawy, U.M. Mohmoud and A.H. Sayed, Fish Physiol. Biochem., 2010, 37-71-84