ANALYSIS OF DENTAL PULP CHANGES OBSERVED AFTER THE LONG TERM USE OF CORTICOSTEROID DRUGS IN LOCAL PATIENTS OF PAKISTAN

Introduction: Corticosteroids are the class of drugs which contain steroid hormones which is naturally produced in the adrenal cortex of animals and analogues of these hormones are also prepared in the laboratory. They involved in a different processes like physiologic processes, stress and immune response, metabolism of carbohydrates and proteins and regulation of inflammation reaction. Objectives of the study: The main purpose of this present study is to analysis of dental pulp changes observed after the long term use of corticosteroid drugs in local patients of Pakistan. Methodology of the study: The study groups were divided into two groups for the collection of data. One group was considered to be as the normal group and control group and the second one was the group of patients who received corticosteroid drugs during the treatment of dental pulp. The data was collected from both the groups for further analysis. Histopathologies of these two groups were also done for further clarification. Results and analysis: Results shows the percentage of vascular pulp area in relation to the total pulp area recorded in the groups. Group I presented significantly higher values (p=0.01) than Group II and Group III, which means a significantly larger vascular area. Conclusion: Under the tested experimental conditions, corticosteroids applied on the dentin proved to reduce the vascular phase of pulp inflammation regarding vessel diameter and number of blood vessels