Synthesis of New Local Anaesthetics. Part IV

Diethylaminoacetyl-2-amino-, -4-methyl-, -5-methyl-, -6-methyl-, -6.chloro-, -6-methoxy-, and -6-ethoxy-benzo­thiazoles and their hydrochlorides have been synthesised and their local anaesthetic activity has been tested. The pharma­cological screening has shown that the hydrochloride of diethylaminoacetyl-2-amino-6-chlorobenzothiazole is the most active of all the compounds described here and diethylaminoacetyl-2-amino-6-methylbenzothiazole is the most active amongst the three methyl derivatives