OSTEOPOROSIS IN CHRONIC KIDNEY DISEASE

Objectives. The aim of this paper is to highlight the clinical manifestations of musculoskeletal disorders in chronic kidney disease. Material and methods. A structured search was performed in the PubMed, Scopus and HINARI databases, where the relevant articles have been taken into account, published in the last 20 years. The search terms used (in english) were: ”osteoporosis”, ”mineral bone disorder and chronic kidney disease”, ”pathogenesis of mineral bone disorder in chronic kidney disease”, ”diagnosis of osteoporosis and chronic kidney disease”. Results. Osteoporosis associated with chronic kidney disease is a complex disease that causes high morbidity and mortality in patients with kidney disease. Patients with chronic kidney disease have an increased risk of osteoporotic fractures. Bone fragility is not only affected by reduced bone volume and mass, but also by poor tissue quality. Dual absorption X-ray osteodensitometry is a very useful clinical method in assessing bone strength and can minimize the risk of fracture in patients with chronic kidney disease. Bone quality and fracture risk in patients with chronic kidney disease can be better assessed by using new technologies, such as high-resolution imaging investigations. Conclusions. Establishing the correct and timely diagnosis of bone problems helps prevent future bone loss and fractures. A detailed understanding of the complex pathogenesis of bone mineral disorders in chronic kidney disease is the key to developing an effective management approach