ANTIUROLITHIATIC POTENTIAL OF Parkia biglobosa, Lannea humilis STEM BARK METHANOL EXTRACT AND KO-888 TONIC

Abstract: Kidney stones affect several biological processes, including urine volume, pH, calcium oxalate, and urates. The aim of the study was to evaluate the antiurolithiatic potential of Parkia biglobosa, Lannea humilis stem bark and KO-888 (Jigsimur). These plants were extracted with methanol using soxhlet extraction. The phytochemical screening was carried out using standard procedures. Renal calculi were induced using ethylene glycol in 55 rats and treated with the extracts and KO-888 for 14 days. The phytochemical contents showed the presence of tannins, saponins, flavonoids, steroids, hydrogen cyanides, glycosides, alkaloids, phenols, and terpenoids with copious concentrations of glycosides, alkaloids, and terpenoids in the plant extracts. While, steroids, hydrogen cyanides, alkaloids, and terpenoids were absent in K0-888 compared to the plant extracts. The MDA level decreased significantly (p<0.05) at all doses in the treatment groups. The SOD activity showed a significant (p<0.05) increase in Lannea humilis and KO-888 at all doses and low dose mixture of Lannea humilis and Parkia biglobosa (50:50). The CAT activity showed a significant (p<0.05) increase in all treated groups. While GPx activity showed a significant (p<0.05) increase in Lannea humilis at a low dose and Parkia biglobosa at a high dose. These antioxidant enzyme effects were less than the standard. The blood urea nitrogen showed a significant (p<0.05) reduction in all treatment groups and the creatinine level showed a significant (p