ORODISPERSIBLE LIQUISOLID COMPACTS – A NOVEL APPROACH TO ENHANCE SOLUBILITY AND BIOAVAILABILITY: A REVIEW

A liquisolid system has the ability to improve the dissolution properties of poorly water-soluble drugs. Liquisolid compacts are flowing and compactable powdered forms of liquid medications. The design of liquisolid systems are mainly intended for enhancement of solubility, dissolution rate and bioavailability of poorly water-soluble and highly lipophilic drugs. Improvement in bioavailability may be due to increased surface area, increased aqueous solubility and increased the wettability of the drug. Orodispersible tablets may give rapid onset of action by rapid absorption through pre-gastric absorption of drug from mouth, pharynx and oesophagus as saliva passes down and beneficial to reduce dose. By combining Liquisolid technique and Orodispersible DDS, may enhance solubility, dissolution rate by means of Liquisolid technique and can achieve rapid onset of action with lower dose of drug by using Orodispersible DDS and hence may increase patient compliance. The current review mainly focuses on theory and applicability of liquisolid compact technique towards solubility or bioavailability enhancement. Different carriers, Non-Volatile Solvents, coating materials, Disintegrant and Methods employed are elucidated. KEYWORDS: liquisolid systems, lipophilic drugs, dissolution, bioavailability, sustained release systems, novel techniqu