COMPARISON BETWEEN PATIENTS WITH POLYCYSTIC OVARY SYNDROME AND CONTROLS IN TERMS OF FASTING SERUM TRIGLYCERIDE LEVELS IN OBESE PATIENTS

Introduction: Polycystic ovary syndrome (PCOS) is an endocrine problem with the set of symptoms such as irregular mensuration, subfertility, acne vulgarius and hirustism in women due to hyperandrogenism. PCOS women in general have dyslipidemia, obesity, type 2 diabetes, cardiovascular abnormalities, endometrial cancer and ovarian cancer too. PCOS patients have abnormal levels of triglycerides, cholesterol and LDL. The serum triglyceride levels (TGL) affected more as compared to other lipid parameters. Elevated levels of triglyceride put the PCOS patients to an increased risk of cardiovasular complications and metabolic perturbations. In addition to many efforts being put in establishing the association between aforementioned diseases and the PCOS internationally, this study is focused on determining the relationship between higher levels of fasting serum triglyceride and the PCOS. Objectives: Comparison between patients with polycystic ovary Syndrome and controls in terms of fasting serum triglyceride levels in obese patients. Material and Methods Study Design: Comparative cross sectional study Setting: Study was conducted in Obstetrics and Gynaecology Department, District Headquarter Hospital, Gujranwala. Subjects: 100 subjects equally divided in 50 women with diagnosed PCOS and 50 women with no PCOS. Each subject group is selected in such a fashion that it further subdivides into 25 women with known family history of dyslipidemia and 25 women with no known family history of dyslipidemia. Study Duration: Six months after the approval of synopsis (from 13th Jan 2018). Results: Mean age of the total population is 27.57 years. Mean age of the PCOS cases is 28.48 years. Mean age of the controls is 26.66 years. Mean of BMIs of total population is 31.849 Kg/m2. Means of BMIs of cases and controls are 31.844 Kg/m2 and 31.854 Kg/m2 respectively. Mean of Serum Triglyceride of total population is 257.62 mg/dl. Means of Serum Triglyceride of cases and controls are 285.46 mg/dl and 229.78 mg/dl respectively. Serum Triglyceride and PCOS have a significant likelihood. PCOS and non-PCOS women have significantly different mean values of Serum Triglyceride. A significant 8.2% variance in Serum Triglyceride is correlated to PCOS. Serum Triglyceride and Family History of Dyslipidemia have significant likelihood. BMI and PCOS have no significant association. BMI and Family History of Dyslipidemia have no significant relation. PCOS and Family History of Dyslipidemia have no significant connection. A significant 24.9 % variance in Serum Triglyceride is because of BMI. Conclusion: A significant likelihood between Serum Triglyceride and PCOS is found. Also, PCOS and non-PCOS women are found to have significantly different mean values of Serum Triglyceride. This study found an 8.2% variance in Serum Triglyceride is correlated to PCOS as both had a significant correlation too. These findings corroborate the hypothesis of association between the Serum Triglyceride and PCOS. Keywords: PCOS, Serum Triglyceride, TGL, BMI, Family History of Dyslipidemia