PREPARATION AND EVALUATION OF TASTE MASKING ORAL DISINTEGRATING FILMS OF DICCLOFENAC POTASSIUM USING SOLVENT CASTING METHOD

This research was carried out with the prime objective of taste masking oral disintegrating films of the drug that has undesirable taste like diclofenac potassium which was to enhance agreement among the ageing population, the new born and non compliant patient which facilitates the ease of its passage. The reason of this study was carried out to understand film forming properties of various ingredients like HPMC, Pullulan and polyvinyl alcohol polyethylene glycol based polymers that were used in these experiments. The folding endurance test , the way it peels and its disintegration time (in vitro) of plasticizers that included propylene glycol, sorbitol, glycerin polyethylene glycol 400 was evaluated . The method that was used to prepare it here was solvent casting method. The non placebo films containing the drug that consisted of the polymers with its plasticizer showed the best possible film forming capacity having an accepting folding endurance and a good disintegration time of 22 seconds and greater than 95 % of drug release within 10 minutes of time that was better than the tablets that were marketed and immediate release which gave a value of almost 30.4 % at the end of 10 minutes time. The films that were prepared were in the range of 30 – 40 milligram. It was taste masked by a mixture called as sucralose and monoammonium glycerrhizinate giving the best sweetness profile. The stability studies carried out on these ODT films showed that these were stable atleast for 3 months when it was stored at 40°C and that was having 75 % Relative Humidity. This formulation that was prepared was effortless and simple having least cost whenever there is a need to deliver the medicine especially in cases like joint stiffness where immediate onset of action was quite necessary. Keywords: Oral Disintegrating Film, Monoammonium Glycerrhizinate, Folding endurance, Solvent Casting, Diclofenac Pottasium