CHEMICAL PROFILING AND ADME PREDICTION OF SARACA ASOCA (ROXB) WILDE

The dried powdered bark of Saraca asoca was extracted using ethyl acetate, acetone, ethanol and distilled water by a three-step sequential extraction procedure. Among all extracts, ethanolic extract showed highest phenol (438.78±0.86 mg/g gallic acid equivalent), proanthocyanidins (0.8±0.05) and coumarin (1.192±0.2 mg/g) content while highest flavonoid (179.5±0.47 mg/g rutin equivalent) were detected in ethyl acetate extract. Highest DPPH free radical quenching activity was observed in ethanolic extract of Saraca asoca (IC50 value 48.43) which was significantly comparable with ascorbic acid (IC50 value 14.12). The UV-visible and FTIR spectrum confirmed the presence of alcohols, phenols, alkanes, alkyl halides, aldehydes, carboxylic acids, aromatics, nitro compounds and amines in ethanolic extract. The FTIR, GC-MS spectrum profile along with the (ADME)-Toxicity analysis unveiled that the medicinally important plant Saraca asoca bark extract having various bioactive compounds and can be used as therapeutic agents