Lambda interferons (IFNL, IFN-λ) are pro-inflammatory cytokines important in acute and chronic viral infection. Single-nucleotide polymorphisms rs12979860 and rs8099917 within the IFNL gene locus predict hepatitis C virus (HCV) clearance, as well as inflammation and fibrosis progression in viral and non-viral liver disease. The underlying mechanism, however, is not defined. Here we show that the rs12979860 CC genotype correlates with increased hepatic metallothionein expression through increased systemic zinc levels. Zinc interferes with IFN-λ3 binding to IFNL receptor 1 (IFNLR1), resulting in decreased antiviral activity and increased viral replication (HCV, influenza) in vitro. HCV patients with high zinc levels have low hepatocyte antivi...
Background & Aims: Genetic variations near the interferon lambda 3 gene (IFNL3, IL28B) are the m...
IFNL3/IFNL4 polymorphisms are inversely associated with the risk of chronic hepatitis C virus (HCV) ...
For two decades the scientific community has sought to understand why some people clear hepatitis C ...
Lambda interferons (IFNL, IFN-λ) are pro-inflammatory cytokines important in acute and chronic viral...
Lambda interferons (IFNL, IFN-λ) are pro-inflammatory cytokines important in acute and chronic viral...
Lambda interferons (IFNL, IFN-λ) are pro-inflammatory cytokines important in acute and chronic viral...
The IFNL3 genotype predicts the clearance of hepatitis C virus (HCV), spontaneously and with interfe...
Abstract Background Impact of interleukin 28B (IL28B) rs12979860 polymorphism on response to direct-...
Hepatitis C virus (HCV) infections are the major cause of chronic liver disease, cirrhosis and hepat...
The human interferon (IFN) response is a key innate immune mechanism to fight virus infection. IFNs ...
The human interferon (IFN) response is a key innate immune mechanism to fight virus infection. IFNs ...
Metallothioneins (MTs) are small, cysteine-rich proteins characterized by a high affinity for monova...
For two decades the scientific community has sought to understand why some people clear hepatitis C ...
For two decades the scientific community has sought to understnad why some people clear hepatitis C ...
BACKGROUND & AIMS: Genetic variations near the interferon lambda 3 gene (IFNL3, IL28B) are the most ...
Background & Aims: Genetic variations near the interferon lambda 3 gene (IFNL3, IL28B) are the m...
IFNL3/IFNL4 polymorphisms are inversely associated with the risk of chronic hepatitis C virus (HCV) ...
For two decades the scientific community has sought to understand why some people clear hepatitis C ...
Lambda interferons (IFNL, IFN-λ) are pro-inflammatory cytokines important in acute and chronic viral...
Lambda interferons (IFNL, IFN-λ) are pro-inflammatory cytokines important in acute and chronic viral...
Lambda interferons (IFNL, IFN-λ) are pro-inflammatory cytokines important in acute and chronic viral...
The IFNL3 genotype predicts the clearance of hepatitis C virus (HCV), spontaneously and with interfe...
Abstract Background Impact of interleukin 28B (IL28B) rs12979860 polymorphism on response to direct-...
Hepatitis C virus (HCV) infections are the major cause of chronic liver disease, cirrhosis and hepat...
The human interferon (IFN) response is a key innate immune mechanism to fight virus infection. IFNs ...
The human interferon (IFN) response is a key innate immune mechanism to fight virus infection. IFNs ...
Metallothioneins (MTs) are small, cysteine-rich proteins characterized by a high affinity for monova...
For two decades the scientific community has sought to understand why some people clear hepatitis C ...
For two decades the scientific community has sought to understnad why some people clear hepatitis C ...
BACKGROUND & AIMS: Genetic variations near the interferon lambda 3 gene (IFNL3, IL28B) are the most ...
Background & Aims: Genetic variations near the interferon lambda 3 gene (IFNL3, IL28B) are the m...
IFNL3/IFNL4 polymorphisms are inversely associated with the risk of chronic hepatitis C virus (HCV) ...
For two decades the scientific community has sought to understand why some people clear hepatitis C ...