Facile synthesis of 1,3,4-thiadiazole appended to coumarins as antimicrobial agents

Post-Graduate Department of Studies in Chemistry, Karnatak University, Dharwad-580 003, Karnataka, India E-mail : kamchem9@gmail.com Fax : 91-836-2747884 Manuscript received 21 September 2010, accepted 30 December 2010 A new series of N-[4-acetyl-4,5-dihydro-5-methyl-5-(6, 7-disubstituted-coumarin-3' -yl)-1 ,3,4-thiadiaJ:ol-2-yl]-acctamide (4a-f) were synthesized from semicarbazones 3a-f and acetic anhydride. The structure of all the synthesized compounds was confirmed by analytical and spectral (IR, 1H, 13C NMR and MS) data. All the compounds were screened for their pharmacological parameters for bioavailability using Osiris property explorer. Amongst the title compounds 4a, 4d and 4e have shown excellent drug likeliness and drug score values and did not exhibit any drug toxicity viz. mutagenicity, tumorigenicity, reproductive effect and irritant nature. Eventually these compounds arc biologically safe for intake